Osteogenic potential of cells in vitro derived from haemarthrosis of the knee induced by injury to the anterior cruciate ligament.
نویسندگان
چکیده
We have investigated whether cells derived from haemarthrosis caused by injury to the anterior cruciate ligament could differentiate into the osteoblast lineage in vitro. Haemarthroses associated with anterior cruciate ligament injuries were aspirated and cultured. After treatment with beta-glycerophosphate, ascorbic acid and dexamethasone or 1,25 (OH)(2)D(3), a significant increase in the activity of alkaline phosphatase was observed. Matrix mineralisation was demonstrated after 28 days and mRNA levels in osteoblast-related genes were enhanced. Our results suggest that the haemarthrosis induced by injury to the anterior cruciate ligament contains osteoprogenitor cells and is a potential alternative source for cell-based treatment in such injury.
منابع مشابه
Relationship between kinematic parameters of the lower limb and maximum ground reaction force during jumping and one-legged landing
Background: Anterior cruciate ligament injury is one of the most common injuries of the knee joint and prevention of this injury is of great importance(1). Considering that ground reaction forces are one of the load factors on the anterior cruciate ligament, Despite much research in this field to prevent ACL injury, the prevalence of this injury is still high(2). For example, previous studies h...
متن کاملFluoroscopic analysis of anterior tibial translation during eccentric and concentric phase of knee rehabilitation exercises in men with anterior cruciate ligament injury
Background: The amount of anterior tibial translation during rehabilitation exercises is a key factor in organizing exercise regimen after anterior cruciate ligament injury. Excessive anterior tibial translation could increase the magnitude of tension imposed on injured and reconstructed anterior cruciate ligament knees. Forward lunge and open-kinetic knee extension exercises are commonly used ...
متن کاملComparison the Effect Plyometric Exercises with and without Stretching Exercises on Dynamic Knee Valgus, Flexibility and Functional Factors on Female Elite Taekwondo Athletes Exposed to Anterior Cruciate Ligament Injury
The prevalence of sports injuries in martial arts is high. Most Taekwondo injuries also occur in the lower extremities. The aim of this study is to compare the effect of a period of plyometric exercises, with and without stretching exercises, on knee valgus dynamics, flexibility and functional variables of elite female taekwondo athletes at risk of anterior cruciate ligament injuries. 45 elite...
متن کاملتحلیل دامنه حرکتی و سرعت زاویه ای مفاصل اندام تحتانی در بیماران دارای رباط صلیبی قدامی بازسازی شده هنگام فرود از ارتفاع
Aims and background: Anterior cruciate ligament injury is the most common ligament injury of the lower limb that necessitates reconstruction as a proper treatment approach. It is now up to the researchers to ask, are the altered kinematic patterns in the lower limbs corrected by this reconstruction? The present study aims to analyze the range of motion and angular velocity of the lower limb jo...
متن کاملEffect of Fatigue on Ground Reaction Force Variables During Single-leg Landing in Athletes With the History of Anterior Cruciate Ligament Injury
Introduction: Since people experience fatigue after anterior cruciate ligament injury during exercises, it is important to understand how fatigue affects the biomechanical movement patterns. Therefore, this study aimed to investigate the effect of fatigue on ground reaction force variables during single-leg landing in athletes with a history of an anterior cruciate ligament spr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of bone and joint surgery. British volume
دوره 88 1 شماره
صفحات -
تاریخ انتشار 2006